Monkeypox is a viral disease caused by infection with the monkeypox virus. Monkeypox symptoms are similar to smallpox symptoms, but milder, and monkleypox is rarely fatal. Monkeypox was discovered in 1958 when two outbreaks of a pox-like disease occured in colonies of monkeys kept for research. Despite being named "monkeypox," the source of the disease remains unknown. However, African rodents and non-human primates (like monkeys) might harbor the virus and infect people.
"People with advanced HIV infection or who are not taking antiretroviral drugs might be at increased risk for severe disease if they get monkeypox. Monkeypox can be treated with the antiviral drug tecovirimat (TPOXX). No identified drug interactions would prevent someone with HIV from taking tecovirimat with antiretroviral drugs. Pre- and post exposure prophylaxis can be considered with the JYNNEOS vaccine. Although there are little data about monkeypox in patients with HIV, prompt diagnosis, prevention, and treatment might help prevent adverse outcomes and limit the spread of monkeypox."